Selenium sulfide: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Dandruff, Seborrhoeic dermatitis

Adult: As 2.5% shampoo or lotion: Massage into wet scalp, leave for 2-3 min then rinse thoroughly. Use twice weekly for 2 weeks, may repeat at less frequent intervals subsequently. As 1% shampoo or lotion: Apply 1-2 times weekly.
Child: 5-14 yr Same as adult dose.

Topical/Cutaneous
Tinea versicolor

Adult: As 2.5% lotion: Apply to affected areas, lather w/ a small amount of water and leave on skin for 10 min, then rinse thoroughly. Repeat procedure once daily for 7 days.

Contraindications

Hypersensitivity. Broken or severely inflamed skin.

Special Precautions

Childn. Pregnancy and lactation.

Adverse Reactions

Skin irritation, esp in the genital areas and skin folds; oily scalp, hair discouloration, hair loss.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Remove gold, silver and other metallic jewellery prior to use. Avoid use of shampoo w/in 48 hr of applying hair dye, straightening or waving preparations.

Action

Description:
Mechanism of Action: Selenium sulfide has antifungal and antiseborrhoeic properties. It is active against Pityrosporum ovale, a yeast-like fungus that is part of the normal flora of the scalp. It also has a cytostatic effect on cells of the epidermis and follicular epithelium, thus reducing corneocyte production.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Psoriasis, Seborrhea & Ichthyosis Preparations

ATC Classification

D01AE13 - selenium sulfide ; Belongs to the class of other antifungals for topical use.

References

Anon. Selenium Sulfide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 20/05/2016.

Buckingham R (ed). Selenium Sulfide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/05/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Selenium Sulfide. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 20/05/2016.

Selenium Sulfide Lotion (Perrigo New York Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 20/05/2016.

Selenium Sulfide Shampoo (Bi-Coastal Pharma International LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 20/05/2016.

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